Blood Tests for Diagnosing Hepatitis B

The &#;Hepatitis B Panel&#; of Blood Tests*

The &#;Hepatitis B Panel&#; of Blood Tests*

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Only one sample of blood is needed for a hepatitis B blood test with the &#;Hepatitis B Panel&#; that includes three parts. All three test results are needed to fully understand a person&#;s hepatitis B status**.

Below is an explanation of the 3-part &#;Hepatitis B Panel&#; of blood test results. 

1. HBsAg (Hepatitis B surface antigen) - A "positive" or "reactive" HBsAg test result indicates that a person is infected with hepatitis B. This test can detect the presence of the hepatitis B virus (called the &#;surface antigen&#;) in the blood. If a person tests &#;positive,&#; then further testing is needed to determine if this is a new &#;acute&#; infection or a &#;chronic&#; hepatitis B infection.
2. anti-HBs or HBsAb (Hepatitis B surface antibody) - A "positive" or "reactive" anti-HBs (or HBsAb) test result indicates that a person is protected against the hepatitis B virus. This protection can be the result of receiving the hepatitis B vaccine or successfully recovering from a past hepatitis B infection. A positive anti-HBs (or HBsAb) test result indicates that a person is &#;immune&#; and protected against the hepatitis B virus and cannot be infected.
3. anti-HBc or HBcAb total (Hepatitis B core antibody) - A "positive" or "reactive" anti-HBc (or HBcAb) test result indicates that a person has been exposed to the hepatitis B virus at some point during their life. A positive HBcAb test alone cannot tell if a person has a past or current hepatitis B infection. The core antibody does not provide any protection against the hepatitis B virus (unlike the surface antibody described above). This test can only be fully understood by knowing the results of the first two tests (HBsAg and anti-HBs). A positive anti-HBc (or HBcAb) test result requires talking to a knowledgeable health care provider for a complete explanation of your hepatitis B status.

* Not all of the above blood tests are routinely performed as part of blood donation screening. If you test positive for any of these tests, please see your health care provider for advice!

**If you are in the U.S., ask your doctor to test you for hepatitis B. The U.S. Centers for Disease Control and Prevention (CDC) now recommends that all adults 18 and older be screened at least once in their lifetime. You can read more about it here.

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HBsAg is the surface antigen of Hepatitis B virus (HBV). HBsAg is known to be present in blood if HBV infected patients, and used as a important diagnostic maker of HBV infection. HBsAg forms a small lipid particle&#;diameter 50 to 60nm&#;in which many antigen protein are present. Each antigen protein has three domains, called S, Pre-S1 and Pre-S2. L-type antigen contains all the three domains, M-type antigen contains S- and Pre-S2, and S-type antigen consisted of only S-domains. During the process of HBV infection, Pre-S1 domain plays a key role for host (hepatic) cell recognition, and Pre-S2 domain is essential for cell penetration. In infected patients, hepatic cells produces a lot of non-infectious S-type HBsAg (HBV mimetics without genome). The detection of serum Pre-S2 and Pre-S1 antigen is, therefore, very important to reveal the mechanism of HBV infection. Beacle has over a decade of R&D history on HBsAg and related materials. In this page we introduce HBsAg-related antibodies. All antibodies listed here are good for western blot and ELISA.

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Our HBs antibodies are raised against recombinant antigens. They are generally good for western and ELISA.

Types of antibodies

1. Anti-HBs Pre-S1 antibodies (monoclonal)
Mouse monoclonal antibody against Pre-S1 reagion. Two types of anti-Pre-S1 monoclonal antibodies are available. Both products can be used for Western blotting. A sandwich ELISA system can be established by using these two antibodies or with below polyclonal antibody. For detail see Pre-S1 mono datasheet. &#;Pre-S1 detecting ELISA kit&#; is also available. Click here for &#;ELISA kit&#;.

2. Anti-HBs Pre-S1 antibody&#;polyclonal&#;
Polyclonal antibody raised against HBs Pre-S1 peptide in rabbit. Three types are available, these antibodies differ in their recognition of HBV genotypes. The products can be used for western and ELISA. For the detail please check Pre-S1 polyclonal antibody datasheet. &#;Pre-S1 detecting ELISA kit&#; is also available. Click here for &#;ELISA kit&#;.

3. Anti-HBs Pre-S2 antibody&#;monoclonal&#;
Mouse monoclonal antibody against Pre-S2 reagion. Two types of antibodies are available, these antibodies considerably differ in their recognition of HBV genotypes. The product is useful for western blot and ELISA. For detail see Pre-S2 monoclonal antibody datasheet. &#;Pre-S2 detecting ELISA kit&#; is also available. Click here for &#;ELISA kit&#;.

4. Anti-HBs Pre-S2 antibody&#;polyclonal&#;
Polyclonal antibody raised against HBs Pre-S2 peptide in rabbit. The product can be used for western and ELISA. For the detail please check Pre-S2 polyclonal antibody datasheet. &#;Pre-S2 detecting ELISA kit&#; is also available. Click here for &#;ELISA kit&#;.

5. Anti-HBs S antibody&#;monoclonal&#;
Monoclonal antibody raised against HBs S-protein (so called HBsAg) in mouse. Two types of antibodies are available, these antibodies considerably differ in their recognition of HBV genotypes. The product can be used for western, and ELISA. For the detail please check HBsAg monoclonal antibody datasheet. &#;HBs S-protein detecting ELISA kit&#; is also available. Click here for &#;ELISA kit&#;.

6. Anti-HBs S antibody&#;polyclonal&#;
Polyclonal antibody raised against HBs S-protein (so called HBsAg) in rabbit. The product can be used for western, and ELISA. For the detail please check HBsAg polyclonal antibody datasheet. &#;HBs S-protein detecting ELISA kit&#; is also available. Click here for &#;ELISA kit&#;.

7. Anti-HBcAg antibody&#;polyclonal&#;
Polyclonal antibody raised against HBV core antigen (so called HBcAg) in rabbit. The product can be used for western, and ELISA. For the detail please check anti-HBcAg polyclonal antibody datasheet

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